Srta, researchers monitored and quantified

Researchers from Yale University and Yale School of Medicine is included

stepchild of small molecules on the walls of bacterial cells

manipulation of biosynthetic routes endogenous bacterial enzymes. This technique

help further studies of bacteria and may lead to new

antibacterial therapy as well as methods to make cell walls more susceptible

on nonnative molecules could improve patient treatment. Often the most difficult barrier to antibiotic or immunogenic molecule

its entry into the bacterial cell. In considering ways to do

different pathophysiological disease are more susceptible to immunogenic >> << molecules Yale team came across Srta, bacterial enzyme that facilitates

inclusion of molecules in the cell wall, organelles

, that communicates with internal and external molecules. I was intrigued by the idea of ​​food bacteria substrates, which significantly

capture bacteria native biosynthetic process target the same

bacteria to the immune system killing, says study co-author David Spiegel, >> << assistant professor of chemistry at Yale University. To test whether they can control bacterial functions >> << fluorescent probe attached to a small peptide with a known motive for the recognition >> << Srta, LPETG. Then the team used the enzyme Srta include

fluorophore in clinically important pathogens

Staphyloccus aureus,

which is notorious serovars methicillin-resistant S.

Aureus (MRSA) was

widely discussed in the media. The natural way of biosynthesis can unlock bacteria by embedding molecules

, allowing easy passage through the cell wall. According >> << command results, fluorescent probes were included in the

Staphylococcus aureus strattera no prescritpion cell wall of Srta, researchers monitored and quantified

place and scope probes combined with epifluorestsentnoy and

electron microscopy, biochemical production, and mass spectrometry. Spiegel has high hopes for the future immunogenic and anti-bacterial adaptation

protocol is fairly simple for laboratories that do

No synthetic chemistry expertise. He already began to study some of these options

in his laboratory in different species of bacteria. We wanted to make small molecules that can interact with antibodies that

already present in the human blood stream, said Spiegel, and thus

, that create a common mechanism induced cytotoxicity, which could

apply to all types of different diseases. The document was published October 5, 2010 in

American Chemical Biology Chemical Society. .